Astonishing Hypothesis: The Scientific Search for the Soul - Softcover

Francis Crick is the British physicist and biochemist who collaborated with James D. Watson in the discovery of the molecular structure of DNA, for which they received the Nobel Prize in 1962. He is the author of What Mad Pursuit, Life Itself, and Molecules and Men. Dr. Crick lectures widely all over the world to both professional and lay audiences, and is a Distinguished Research Professor at the Salk Institute in La Jolla, California.

Chapter 1

Introduction
Q: What is the soul?

A: The soul is a living being without a body, having reason and free will.

Roman Catholic catechism

The Astonishing Hypothesis is that "You," your joys and your sorrows, your memories and your ambitions, your sense of personal identity and free will, are in fact no more than the behavior of a vast assembly of nerve cells and their associated molecules. As Lewis Carroll's Alice might have phrased it: "You're nothing but a pack of neurons." This hypothesis is so alien to the ideas of most people alive today that it can truly be called astonishing.

The interest of human beings in the nature of the world, and about their own natures in particular, is found in one form or another in all peoples and tribes, however primitive. It goes back to the earliest times from which we have written records and almost certainly from before that, to judge from the widespread occurrence of careful human burial. Most religions hold that some kind of spirit exists that persists after one's bodily death and, to some degree, embodies the essence of that human being. Without its spirit a body cannot function normally, if at all. When a person dies his soul leaves the body, although what happens after that -- whether the soul goes to heaven, hell, or purgatory or alternatively is reincarnated in a donkey or a mosquito -- depends upon the particular religion. Not all the religions agree in detail, but this is usually because they are based on different revelations -- contrast the Christian Bible and the Muslim Koran. In spite of differences among religions, there is broad agreement on at least one point: People have souls, in the literal and not merely the metaphorical sense. These beliefs are held, and in many cases held strongly and aggressively, by the majority of human beings alive today.

There are, of course, a few exceptions. At one point, a minority of some of the more extreme Christians (following Aristotle) doubted whether women had souls, or at least had souls of the same quality as men. Some religions, such as Judaism, put little emphasis on life after death. Religions differ as to whether animals have souls. An old joke suggests that philosophers (in spite of all their differences) fall broadly into two classes: Those who own dogs, it is said, are confident that dogs have souls; those who do not, deny this.

Yet a minority of people today (including a large number in the former Communist countries) is inclined to a totally different view. Such people believe that the idea of a soul, distinct from the body and not subject to our known scientific laws, is a myth. It is easy to see how such myths could have arisen. Indeed, without a detailed knowledge of the nature of matter and radiation, and of biological evolution, such myths appear only too plausible.

Why, then, should this basic concept of the soul be doubted? Surely if almost everyone believed it, this is, in itself, prima facie evidence for it. But then some four thousand years ago almost everyone believed the earth was fiat. The main reason for this radical change of opinion is the spectacular advance of modern science. Most of the religious beliefs we have today originated in a time when the earth, while a small place by our standards, was then thought of as being very large, even though its exact extent was unknown. Any one person had direct knowledge of only a tiny part of it. It was not implausible to believe that this large earth was the center of the universe and that man occupied the leading place in it. The earth's origins seemed lost in the mists of time and yet the span of time thought to be involved, while it seemed long in terms of human experience, we now know to be ridiculously short. It was not implausible to believe the earth was less than ten thousand years old. We now know its true age is about 4.6 billion years. The stars seemed far away, fixed perhaps in the spherical firmament, but that the universe extended as far as it does more than 10 billion light years -- was almost inconceivable. (An exception has to be made here for certain Eastern religions, such as Hinduism, that take pleasure in inflating times and distances for the sheer joy of it.)

Before Galileo and Newton our knowledge of basic physics was primitive. The movements of the sun and the planets seemed to be regular in some very intricate way. It was not totally unreasonable to believe that they needed angels to guide them. What else could make their behavior so regular? Even in the sixteenth and seventeenth centuries our understanding of chemistry was largely incorrect. Indeed, the existence of atoms was doubted by some physicists as late as the beginning of the twentieth century.

Yet today we know a great deal about the properties of atoms. We can give each type of chemical atom a unique whole number. We know their structure in detail, and most of the laws that control their behavior. Physics has provided a framework of explanation for chemistry. Our detailed knowledge of organic chemical molecules is enormous and expanding every day.

Admittedly, we still do not understand exactly what happens at very small distances (within the nucleus of an atom), at extremely high energies, and in very large gravitational fields. But for the conditions we normally have to deal with on earth (when an atom will only change into another atom under very special circumstances), most scientists think that this incompleteness of our knowledge probably matters very little, if at all, in our attempts to understand the mind and the brain.

In addition to our knowledge of basic chemistry and physics, the earth sciences (such as geology) and cosmic science (astronomy and cosmology) have developed pictures of our world and our universe that are quite different from those common when the traditional religions were founded. The modern picture of the universe, and how it developed in time, forms an essential background to our present knowledge of biology. That knowledge has been completely transformed in the last 150 years. Until Charles Darwin and Alfred Wallace independently hit on the basic mechanism driving biological evolution -- the process of natural selection -- the "Argument from Design" appeared to be unanswerable. How could an organism as complex and well designed as man have arisen without the help of an all-wise Designer? Yet this argument has collapsed completely. We now know that all living things, from bacteria to ourselves, are closely related at the biochemical level. We know that life has existed on earth for billions of years, and that the many species of plants and animals have changed, often radically, over that time. The dinosaurs have gone and in their place many new species of mammals have arisen. We can watch the basic processes of evolution happening today, both in the field and in our test tubes.

In this century there has been an equally dramatic biological advance, due to our understanding of the molecular nature of genes, the processes involved in their exact replication, together with our detailed knowledge of proteins and the mechanisms of their synthesis. We now realize that proteins, as a class, are immensely powerful and versatile, and can form the basis of elaborate biochemical devices. A major assault is being mounted on embryology (now often called "developmental biology"). The fertilized egg of a sea urchin normally divides many times, eventually turning into a mature sea urchin. If, after the first division, the two daughter cells of the fertilized egg are separated, then each of them will develop, in time, into a separate though rather smaller sea urchin. A similar experiment can be done on a frog's egg. The molecules have reorganized themselves to produce two little animals from the material that would otherwise have produced one. When this was first discovered, about a hundred years ago, it was suggested that some kind of immaterial Life Force must surely be at work. It seemed inconceivable that this dramatic doubling of a living creature could ever be explained on a biochemical basis -- that is, using the properties of organic and other molecules and their interactions. Nowadays we feel that we shall have no difficulty in principle in working out how this can happen, although we expect the explanation to be complex. The history of science is littered with statements that something was inherently impossible to understand ("we shall never know of what the stars are made"). In many cases time has shown these predictions to be incorrect.

A modern neurobiologist sees no need for the religious concept of a soul to explain the behavior of humans and other animals. One is reminded of the question Napoleon asked after Pierre-Simon Laplace had explained to him the workings of the solar system: Where does God come into all this? To which Laplace replied, "Sire, I have no need of that hypothesis." Not all neuroscientists believe that the idea of the soul is a myth -- Sir John Eccles is the most notable exception -- but certainly the majority do. It is not that they can yet prove the idea to be false. Rather, as things stand at the moment, they see no need for that hypothesis. Looked at in the perspective of human history, the main object of scientific research on the brain is not merely to understand and cure various medical conditions, important though this task may be, but to grasp the true nature of the human soul. Whether this term is metaphorical or literal is exactly what we are trying to discover.

Many educated people, especially in the Western world, also share the belief that the soul is a metaphor and that there is no personal life either before conception or after death. They may call themselves atheists, agnostics, humanists, or just lapsed believers, but they all deny the major claims of the traditional religions. Yet this does not mean that they normally think of themselves in a radically different way. The old habits of thought die hard. A man may, in religious terms, be an unbeliever but psychologically he may continue to think of himself in much the same way as a believer does, at least for everyday matters.

We need, therefore, to state the idea in stronger terms. The scientific belief is that our minds -- the behavior of our brains -- can be explained by the interactions of nerve cells (and other cells) and the molecules associated with them. This is to most people a really surprising concept. It does not come easily to believe that I am the detailed behavior of a set of nerve cells, however many there may be and however intricate their interactions. Try for a moment to imagine this point of view. ("Whatever he may say, Mabel, I know I'm in there somewhere, looking out on the world.")

Why does the Astonishing Hypothesis seem so surprising? I think there are three main reasons. The first is that many people are reluctant to accept what is often called the "reductionist approach" -- that a complex system can be explained by the behavior of its parts and their interactions with each other. For a system with many levels of activity, this process may have to be repeated more than once -- that is, the behavior of a particular part may have to be explained by the properties of its parts and their interactions. For example, to understand the brain we may need to know the many interactions of nerve cells with each other; in addition, the behavior of each nerve cell may need explanation in terms of the ions and molecules of which it is composed.

Where does this process end? Fortunately there is a natural stopping point. This is at the level of the chemical atoms. Each atom consists of a heavy atomic nucleus, carrying a positive charge, surrounded by an organized cloud of light, negatively charged nimble electrons. The chemical properties of each atom are determined almost entirely by its nuclear charge. The other properties of the nucleus -- its mass, its secondary electrical properties such as the strengths of its dipole, and its quadrupole -- make in most cases only small differences to its chemical properties.

Now, to a first approximation, the mass and charge of the nucleus of an atom never change, at least in the mild environment in which life flourishes on earth. Thus the knowledge of the substructure of the nucleus is not needed for chemistry. It makes no difference that an atomic nucleus is composed of various combinations of protons and neutrons, and that they, in turn, are made up of quarks. All the chemist needs to know about each atom is its nuclear charge in order to explain most of the facts of chemistry. To do this he needs to understand the rather unexpected type of mechanics (called "quantum mechanics") that controls the behavior of very small particles and of electrons in particular. In practice, since the calculations soon become impossibly intricate, he mainly uses various rules-of-thumb that we now can see have a reasonable explanation in terms of quantum mechanics. Below this level he need not venture.

There have been a number of attempts to show that reductionism cannot work. They usually take the form of a rather formal definition, followed by an argument that reductionism of this type cannot be true. What is ignored is that reductionism is not the rigid process of explaining one fixed set of ideas in terms of another fixed set of ideas at a lower level, but a dynamic interactive process that modifies the concepts at both levels as knowledge develops. After all, "reductionism" is the main theoretical method that has driven the development of physics, chemistry, and molecular biology. It is largely responsible for the spectacular developments of modern science. It is the only sensible way to proceed until and unless we are confronted with strong experimental evidence that demands we modify our attitude. General philosophical arguments against reductionism will not do.

Another favorite philosophical argument is that reductionism involves a "category mistake." For example, in the 1920s this could have taken the form that to consider a gene to be a molecule (or as we should say now, part of a matched pair of molecules) would be a category mistake. A gene is one category and a molecule is a quite different category. One can see now how hollow such objections have turned out to be. Categories are not given to us as absolutes. They are human inventions. History has shown that although a category may sound very plausible, it can, on occasion, turn out to be both misconceived and misleading. Recall the four Humors in ancient and medieval medicine: blood, phlegm, choler, and black bile.

The second reason why the Astonishing Hypothesis seems so strange is the nature of consciousness. We have, for example, a vivid internal picture of the external world. It might seem a category mistake to believe this is merely another way of talking about the behavior of neurons, but we have just seen that arguments of this type are not always to be trusted.

Philosophers have been especially concerned with the problem of qualia -- for example, how to explain the redness of red or the painfulness of pain. This is a very thorny issue. The problem springs from the fact that the redness of red that I perceive so vividly cannot be precisely communicated to another human being, at least in the ordinary course of events. If you cannot describe the properties of a thing unambiguously, you are likely to have some difficulty trying to explain those properties in reductionist terms. This does not mean that, in the fullness of time, it may not be possible to explain to you the neural correlate of your seeing red. In other words, we may be able to say that you perceive red if and only if certain neurons (and/or molecules) in your head behave in...